https://www.mcnabcentre.org/overview daily 0.75 2025-07-18 https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/a37c2f22-ff53-44dc-969e-d173851fbc73/ChemEvo2.jpg Overview - The McNab Centre is developing new ways to ‘evolve’ cancer drugs: ‘Chemical Evolution’ meets the ‘Chemputer’ Regius Professors Lee Cronin and Ross Cagan have come together at the McNab to develop a completely new way to ‘evolve’ cancer drugs. Artificial Intelligence, robotics, chemistry, fruit flies, and human-in-a-dish technology are brought together to ‘evolve’ complex drugs previously impossible to imagine. A novel lead to therapies that is fast and cost-effective. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/c33bd0a6-cae3-4410-9e69-ae9ec1033135/IMG_0554.PNG Overview - Metastasis—cells leaving the original tumour for distant sites—remains the primary challenge in cancer Chiara Braconi, Jim Norman, Laura Machesky and others at the McNab are developing and using ‘human-on-a-chip’ technology to better understand how cancer cells interact with the whole body and how this changes the way we treat cancer patients. This method uses artificially grown cells that resemble human organs to simulate human disease. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/1649996153299-K8VRMED0MBXZXANKXSIX/metastasis-noborder.PNG https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/1649996103828-M04R8BRAQTC1M9KCY1TW/cancer-models-noborder.PNG https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/590ebfac-0eea-49e3-aadf-dd964660cea2/drug-development-final.jpg https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Overview https://www.mcnabcentre.org/team daily 0.75 2025-07-18 https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/e285f396-a613-4932-955e-c932a67205d1/Ross+HeadShot2.jpg Team - Ross Cagan, Ph.D. Director Regius Professor of Precision Medicine Royal Society Wolfson Fellow Head, School of Cancer Sciences Strategy & Partnerships Academic Lead, UKRI SiPF Living Laboratory Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/2e7fe834-bb2c-443b-be0f-23eda5920463/Chiara+Braconi+headshot.png Team - Chiara Braconi, M.D.,Ph.D. Co-Director Consultant Medical Oncologist Beatson West of Scotland Cancer Centre Institute of Cancer Sciences Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/71310278-1576-4866-95b3-950be8814a5a/Jim+Norman+headshot2.png Team - Jim Norman,Ph.D. Co-Director Deputy Director CRUK Scotland Institute Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/d2a47c39-123c-46a3-970b-7edab22ee7fc/20220525_175533.jpg Team - Harshit Shah, Ph.D. Senior Scientific Officer CRUK Beatson Institute Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/a6dd11aa-768e-440c-a403-6905afc9988a/Lindsey+Arnott+2.jpg Team - Lindsey Arnott PhD Candidate CRUK Scotland Institute Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/d6709252-14eb-4cd6-9fb5-a4a750cc0ada/Bjork+photo+.jpg Team - Björk Aston PhD candidate University of Glasgow Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/63296413-ba15-44d0-a0f8-df0e81b94a6f/Hammed+pic+2.jpg Team - Hammed Badmos Postdoctoral Fellow University of Glasgow Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/94383d07-5246-45b4-bbdb-1574377d6c3b/Kristine+L+headshot.jpg Team - Kristine Laws Postdoctoral Fellow University of Glasgow Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/77ee2830-7275-4170-943b-bb3a943ecac5/Tom+Moens.jpg Team - Tom Moens Postdoctoral fellow University of Glasgow Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/1894338b-cdf9-4354-a77b-4de6f32a1ca2/Lucy+Somerville+pic.jpg Team - Lucy Somerville PhD Candidate University of Glasgow Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/27075bc2-0ba4-486c-8e5d-e184df1cb6fa/Fellows.png Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/d2cf7b2b-6533-4f18-ada5-f2a901c401d7/Owen+Amos+Lee.jpg Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mcnabcentre.org/scotland daily 0.75 2025-07-18 https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/348fa747-1b67-4679-aa59-4da9ac6e2e7f/u-glasgow.jpg Scotland - Scotland has a long and proud history of innovation in the field of medicine; from pioneering surgical anaesthesia in the 1800s to the discovery of penicillin in 1928. We at the McNab are inspired by this history. We are innovators, taking risks and developing new technologies to push the field forward. Our goal: improve outcomes for cancer patients everywhere. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/afcefa58-033f-4dc4-a03a-391026b03d5c/glasgow-traffic-cone-statue.jpg Scotland - Scotland has important challenges to realise its potential in the 21st century. We have the lowest life expectancy in Western Europe, in part due to diseases like KRAS-driven cancers. These worrying statistics are linked to a plethora of factors, including Scotland’s industrial past. The McNab is focused on cancers that are especially problematic in our community, as well as helping Glasgow’s amazing teachers nurture the next generation of STEM scientists. https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/66787a9b-de3c-403e-9c5d-8eba848fa1a4/biotech-research.jpg Scotland - Today, Scotland is at the forefront of health innovation. Glasgow’s strong oncology vision is organised within the internationally renowned Cancer Research UK (CRUK), Beatson Institute, and Institute of Cancer Sciences (ICS) within the University of Glasgow. The McNab Centre is helping to build a new future of health innovation, an important pathway to a strong economic future. In this way, we embrace our obligations to the Scottish community. https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Scotland https://www.mcnabcentre.org/contact daily 0.75 2021-12-28 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Contact https://www.mcnabcentre.org/cancer-models daily 0.75 2025-07-18 https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/22de6f9c-6b29-4f69-b3ef-78c9db8f1e7c/IMG_0556.PNG Cancer Models - At the McNab, we are developing and using ‘human-on-a-chip’ technology to better understand how cancer cells interact with the whole body and how this changes the way we treat patients. This method uses artificially grown cells that resemble human organs, allowing us to better simulate human disease. Despite their promise, human-based models have limitations when it comes to simulating the whole body. We house several of the world’s elite Drosophila (fruit fly) and mouse cancer scientists. At the McNab, we are combining these different methods into a single, seamless platform. We believe difficult problems require bold and innovative approaches. A fly-mouse-human platform is just one of our innovations. https://www.mcnabcentre.org/metastasis daily 0.75 2025-07-18 https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/613608ab-b2fd-425d-8281-d422d23bf28f/IMG_0558.png Metastasis - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mcnabcentre.org/drug-development daily 0.75 2022-05-28 https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/53186c77-4580-4a82-8e4c-bafef056ed8c/Broad+Chemputer+pic.png Drug Development - Precision medicine is the matching of therapy (such as a drug) with specific aspects of a patient’s disease. Most of these ‘targeted therapies’ are designed to hit a single target, such as KRAS. While a promising approach, these drugs have overall proved limited in providing sustained benefit to the patient. At the McNab, we aim to develop a next generation of drugs that address cancer in the context of the whole body. How? By combining artificial intelligence, sophisticated cancer models, and robotics-based chemistry (Prof. Cronin’s ‘Chemputer’), we seek to use our unique ‘Chemical Evolution’ approach to find new therapeutic spaces. This futuristic approach is unique to the McNab. https://www.mcnabcentre.org/home daily 1.0 2025-07-18 https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/1649996103828-M04R8BRAQTC1M9KCY1TW/cancer-models-noborder.PNG https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/590ebfac-0eea-49e3-aadf-dd964660cea2/drug-development-final.jpg https://images.squarespace-cdn.com/content/v1/61c4e985b1b30a201b978300/1649996153299-K8VRMED0MBXZXANKXSIX/metastasis-noborder.PNG